Olduvai protein domains, encoded primarily by NBPF genes, have been linked to both human brain evolution and cognitive diseases such as autism and schizophrenia. There are six primary domains that comprise the Olduvai family: three conserved domains (CON1-3) and three human lineage-specific domains (HLS1-3), which typically occur as a triplet (HLS1, HLS2 and HLS3). Herein, we present the solution NMR assignment of the backbone chemical shifts of the separate HLS1, 2 and 3 domains of NBPF15. Our data suggest that there is no change in the structure of the separate domains when compared to the full-length triplet (HLS1–HLS2–HLS3). We also demonstrate that there is no direct interaction between the three domains.

中文翻译：

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解决方案 NMR 主链分配揭示了人类谱系特异性 Olduvai 蛋白结构域的无相互作用翻滚。


Olduvai 蛋白结构域主要由 NBPF 基因编码，与人类大脑进化和自闭症和精神分裂症等认知疾病有关。 Olduvai 家族由六个主要结构域组成：三个保守结构域 (CON1-3) 和三个人类谱系特异性结构域 (HLS1-3)，它们通常作为三联体出现（HLS1、HLS2 和 HLS3）。在此，我们提出了 NBPF15 的单独 HLS1、2 和 3 结构域的主链化学位移的解决方案 NMR 分配。我们的数据表明，与全长三联体（HLS1-HLS2-HLS3）相比，单独域的结构没有变化。我们还证明这三个域之间没有直接的相互作用。