PURPOSE To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM). METHODS A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. RESULTS Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both P < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, P < .001) and 25(OH)D (β = .199, P < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D (P < .001) and IGF-1 (P < .001) to MoCA scores were significant, while no cross-effect was observed between them (P = .714). CONCLUSIONS Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes.

中文翻译：

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血清 IGF-1 和维生素 D 水平降低与 2 型糖尿病患者的认知障碍相关。


目的 确定 2 型糖尿病 (T2DM) 患者血清胰岛素样生长因子 1 (IGF-1) 和维生素 D 水平与认知状态的关系。方法 纳入173例T2DM患者，分为轻度认知障碍（MCI）组（n = 94）和正常认知（NC）组（n = 79）。测定并比较IGF-1和25(OH)D水平，分析IGF-1、25(OH)D与认知功能的相关性。结果 MCI 组的胰岛素样生长因子 1 和 25(OH)D 水平显着低于 NC 组（均为 P < .001）。多元逐步回归分析显示，IGF-1 (β = .146，P < .001) 和 25(OH)D (β = .199，P < .001) 独立预测蒙特利尔认知评估 (MoCA) 分数。偏最小二乘回归显示，25(OH)D (P < .001) 和 IGF-1 (P < .001) 对 MoCA 评分的贡献均显着，但未观察到它们之间存在交叉效应 (P = .714）。结论 低血清 IGF-1 和 25(OH)D 水平可以分别预测糖尿病患者认知能力差。