The aim of this study is to investigate the impact of optimal antihypertensive medication on cognitive function. In this 6-month clinical trial, 248 adults were randomly selected by a registry of hypertensive-treated patients (based on a National Hypertension Treatment Program), followed health centers located in Rafsanjan County, Southeast, Iran. Blood pressure was measured 3 times in each appointment pre- and posttreatment. Mini-Mental State Examination was used for cognitive performance evaluation. Paired t test and multiple regression model showed significant correlation between "the differences of systolic and diastolic blood pressure levels" and "cognitive performance in treated patients more than 40 years old." Cognitive performance was not significantly different in patients less than 40 years old post antihypertensive treatment. Cognitive performance scores demonstrated significant increase in responders more than 40 years old post antihypertensive treatment. Antihypertensive treatment in responders with age equal or more than 40 years improves the level of cognitive performance significantly.

中文翻译：

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抗高血压治疗对认知能力的年龄相关影响：老年痴呆症是否能更好地预防？


本研究的目的是调查最佳抗高血压药物对认知功能的影响。在这项为期 6 个月的临床试验中，248 名成年人是由接受高血压治疗的患者登记处（基于国家高血压治疗计划）随机选择的，并跟踪位于伊朗东南部拉夫桑詹县的卫生中心。每次预约治疗前和治疗后测量血压 3 次。使用简易精神状态检查来评估认知表现。配对t检验和多元回归模型显示“收缩压和舒张压水平的差异”与“40岁以上接受治疗的患者的认知表现”之间存在显着相关性。抗高血压治疗后 40 岁以下患者的认知表现没有显着差异。抗高血压治疗后 40 岁以上人群的认知表现评分显着增加。年龄等于或大于 40 岁的响应者的抗高血压治疗可显着提高认知能力水平。