Alzheimer's disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic, limbic, and cognitive behaviors. In present study, we aim to investigate the morphological changes in the Purkinje cells in different cerebellar regions in AD and to correlate them with the underlying AD pathology. Purkinje cells exhibit significant morphometric alterations in AD and prominently in the anterior lobe which is related to higher cognitive functions. The present study gives new insights into the cerebellar pathology in AD and confirms that Purkinje cells pathology is a key finding in AD brains and that AD is characterized by regional-specific atrophy picked in the anterior cerebellar lobe.

中文翻译：

---

阿尔茨海默病的浦肯野细胞病理学。


阿尔茨海默病（AD）是老年痴呆症的主要原因之一。它的临床特征是记忆障碍、智力衰退和专业技能丧失。小脑是分布式神经回路的关键部分，不仅参与运动功能，还参与自主、边缘系统和认知行为。在本研究中，我们的目的是研究 AD 中不同小脑区域浦肯野细胞的形态变化，并将其与潜在的 AD 病理学相关联。浦肯野细胞在 AD 中表现出显着的形态变化，尤其是在前叶，这与较高的认知功能有关。本研究对 AD 的小脑病理学提供了新的见解，并证实浦肯野细胞病理学是 AD 大脑的一个关键发现，并且 AD 的特征是小脑前叶的区域特异性萎缩。