Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen‐activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2, 1‐a]phthalazines obtained by Suzuki coupling are described.

中文翻译：

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咪唑并 [2, 1-a] 酞嗪的合成，p38 MAP 激酶的潜在抑制剂。蛋白质配体结合亲和力的预测

基于分子模型，讨论了 p38 MAPK（丝裂原活化蛋白激酶）潜在抑制剂的药效团，并计算了预测结合亲和力。描述了通过 Suzuki 偶联获得的原始二芳基咪唑并 [2, 1-a] 酞嗪的合成。