In a search for promising antifungal compounds, nine new 3,3'‐ethylenebis(5‐alkyl‐1,3,5‐thiadiazine‐2‐thiones) were synthesized by the reaction of ethylene diamine, carbon disulfide, formaldehyde, and the appropriate alkyl amine. The title compounds were tested for their antifungal activity in vitro against pathogenic (Trichophyton rubrum and Candida albicans), phytopathogenic (Penicillum expansum, Trichoderma hazianum, and Fasarium oxysporum), and aflatoxin producing (Aspergillus flavus) fungi. These compounds exhibited varied inhibitory effects on growth or sporulation of some tested fungal species.

中文翻译：

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3,3'-亚乙基双(5-烷基-1,3,5-噻二嗪-2-硫酮)的合成及抗真菌活性

为了寻找有前景的抗真菌化合物，通过乙二胺、二硫化碳、甲醛和适当的反应合成了 9 种新的 3,3'-亚乙基双（5-烷基-1,3,5-噻二嗪-2-硫酮）。烷基胺。测试了标题化合物对病原体（红色毛癣菌和白色念珠菌）、植物病原体（扩展青霉、黑木霉和尖孢镰刀菌）和产生黄曲霉毒素（黄曲霉）真菌的体外抗真菌活性。这些化合物对一些测试的真菌物种的生长或孢子形成表现出不同的抑制作用。