The enantiomeric resolution of five substituted 2‐(4‐pyridylalkyl)‐1‐ tetralone derivatives has been achieved on three macrocyclic glycopeptide antibiotic chiral stationary phases namely, Chiro‐biotic R, T, and V columns. The mobile phase used was hexane‐ethanol‐ triethylamine (12:8:0.01, v/v/v). The flow rates were 1 mL/min for Chirobiotic T and 2 mL/min for Chirobiotic R and V respectively. The UV detection was carried out at 254 nm. The values of a of the resolved enantiomers of the reported tetralone derivatives were in the range of 1.32 to 2.51 on Chirobiotic R, 2.02 to 2.88 on Chirobiotic T and 1.55 to 2.54 on Chirobiotic V respectively while the values of Rs were in the range of 1.00 to 2.50 on Chirobiotic R, 1.00 to 1.95 on Chirobiotic T and 1.00 to 1.60 on Chirobiotic V respectively. The best resolution was achieved on Chirobiotic R column.

中文翻译：

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正相模式下使用 HPLC 对几种四氢萘酮衍生物在大环抗生素手性固定相上的对映体拆分的比较研究

五种取代的 2-(4-吡啶基烷基)-1-四氢萘酮衍生物的对映体拆分已在三种大环糖肽抗生素手性固定相即 Chiro-biotic R、T 和 V 色谱柱上实现。使用的流动相是己烷-乙醇-三乙胺（12:8:0.01，v/v/v）。Chirobiotic T 的流速分别为 1 mL/min，Chirobiotic R 和 V 的流速分别为 2 mL/min。UV检测在254nm处进行，所报道的四氢萘酮衍生物的解析对映异构体的a值在Chirobiotic R上为1.32至2.51，在Chirobiotic T上为2.02至2.88，在Chirobiotic V上为1.55至2.54 Rs 的值分别在 Chirobiotic R 的 1.00 至 2.50 范围内，Chirobiotic T 的 1.00 至 1.95 和 Chirobiotic V 的 1.00 至 1.60。