A series of 1H,3H‐thiazolo[3,4‐a]benzimidazoles were synthesized and tested for their in vitro antitumour activity against 60 human tumour cell lines. Some derivatives exhibited both tumour growth inhibition activity and cellular selectivity. In particular, compound 8c, the most active of the series, was very active towards all cell lines at concentrations ranging from 10−7 −10−5 M. Compound 4a, on the other hand, was highly selective against the CNS cancer cell line.

中文翻译：

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1H,3H-噻唑并[3,4-a]苯并咪唑衍生物的合成及抗肿瘤活性

合成了一系列 1H,3H-噻唑并[3,4-a]苯并咪唑，并测试了它们对 60 种人类肿瘤细胞系的体外抗肿瘤活性。一些衍生物表现出肿瘤生长抑制活性和细胞选择性。特别是，该系列中最活跃的化合物 8c 在 10-7 -10-5 M 的浓度范围内对所有细胞系都非常活跃。另一方面，化合物 4a 对 CNS 癌细胞系具有高度选择性.