The preparation of new diblock copolypeptide hydrogels derived from homologs of l‐methionine, that is, l‐homomethionine and l‐6‐(methylthio)‐l‐norleucine is described. Compared to l‐methionine residues, use of l‐methionine homologs allow improved copolymerization with l‐leucine residues to give well‐defined block copolypeptides. These copolypeptides are subsequently modified using robust thioether alkylation reactions employing a variety of functional epoxides, which yield samples capable of forming transparent, self‐healing hydrogels in water. The facile variation of different functional epoxides for postpolymerization modification is found to allow predictable functionalization and tuning of hydrogel properties by the modification of simple precursors.

中文翻译：

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基于蛋氨酸同源物的可调节功能性双嵌段共多肽水凝胶。

从的同源物衍生的新的双嵌段共聚的水凝胶的制备升-甲硫氨酸，即，升-homomethionine和升-6-（甲硫基） -升-norleucine进行说明。与l-蛋氨酸残基相比，使用l-蛋氨酸同系物可以改善与l-蛋氨酸的共聚亮氨酸残基可提供明确的嵌段共多肽。随后，使用各种功能性环氧化物，通过强大的硫醚烷基化反应对这些共多肽进行修饰，产生的样品能够在水中形成透明的，可自愈的水凝胶。发现用于后聚合修饰的不同功能性环氧化物的容易变化允许通过简单前体的修饰来可预测的功能化和水凝胶性质的调节。