Canine cutaneous mast cell tumors (MCTs) are among the most common canine cutaneous tumors, with highly variable biological behavior. This review describes in detail current approaches for cytologic and histologic diagnosis and prognosis, including advantages and limitations of cytologic and histologic grading and utilization of molecular markers, for example, Ki67, AgNORs, KIT expression, and c-Kit mutations, for a more accurate detection of aggressive MCTs. Furthermore, the current approach to evaluate surgical margins and spread to local lymph nodes is discussed.

中文翻译：

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犬皮肤肥大细胞瘤的诊断和预后。

犬皮肤肥大细胞肿瘤（MCT）是最常见的犬皮肤肿瘤，具有高度可变的生物学行为。这篇综述详细描述了细胞学和组织学诊断和预后的当前方法，包括细胞学和组织学分级的优势和局限性以及分子标记（例如，Ki67，AgNOR，KIT表达和c-Kit突变）的利用，以便更准确检测攻击性MCT。此外，讨论了当前评估手术切缘和扩散至局部淋巴结的方法。