Tumor microenvironment represents a key obstacle for the effectiveness of anticancer drugs. Electrochemotherapy involves the systemic or local delivery of lipophobic drugs such as bleomycin and cisplatin, with the application of permeabilizing electric pulses having appropriate amplitude and waveforms. This greatly enhances the uptake of these drugs by an estimated factor of 700-fold for bleomycin and 4 to 8 times for cisplatin. Because of its efficacy and limited morbidity, this therapeutic option is becoming more and more available in veterinary oncology either as an adjuvant to surgery or as first line of treatment with palliative or curative purposes.

中文翻译：

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兽医肿瘤学中的电化学疗法：最新技术和观点。

肿瘤微环境是抗癌药有效性的关键障碍。电化学疗法涉及通过应用具有适当幅度和波形的可透化电脉冲，对诸如博来霉素和顺铂的疏脂药物进行全身或局部递送。这大大提高了这些药物的吸收率，其中博来霉素的吸收率估计提高了700倍，顺铂的吸收率提高了4到8倍。由于其功效和有限的发病率，这种治疗选择在兽医肿瘤学中变得越来越可用，可以作为外科手术的辅助手段或作为姑息或治愈目的的一线治疗方法。