Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

基于介孔二氧化硅纳米粒子（MSN）的杂化材料因其化学多功能性而引起了广泛的关注，药物输送系统（DDS）领域也不例外。MSN具有理想的生物相容性，较高的表面积值以及经过精心研究的表面反应性，可用于定制多种化学部分。对于DDS应用特别重要的是使用外部刺激进行药物释放。在这种情况下，由于其高度的时空精度和非侵入性，光是一种特殊的替代品，最近已经报道了许多基于偶氮苯的可光转换特性的有前途的DDS。