Annual Review of Animal Biosciences ( IF 12.0 ) Pub Date : 2020-02-18 , DOI: 10.1146/annurev-animal-021419-083756 Amir Ghorbani 1, 2 , John M Ngunjiri 1 , Chang-Won Lee 1, 2
The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described “incomplete” virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development.
中文翻译：
甲型流感病毒亚群及其在发病机理和疫苗开发中的意义。
甲型流感病毒（IAV）亚群的概念出现在大约75年前，当时Preben von Magnus描述了“不完整”的病毒颗粒，这些颗粒干扰了传染性病毒的复制。现在已被广泛接受，感染性颗粒仅占生物活性IAV亚群的一小部分。IAV准种是生物和遗传异质颗粒亚群的一个极其多样化的群体，它们共同影响该病毒的进化适应性。这篇综述总结了IAV亚群的当前知识，重点是它们的生物学和基因组多样性。它还讨论了IAV亚群在病毒发病机理和减毒活疫苗开发中的潜在作用。
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