BACKGROUND Several studies suggest that early-life exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization. OBJECTIVES The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma. METHODS The study included 51 children aged 5-18 years, both sexes, allergic to cats. Sensitization to cat allergen was confirmed by skin prick tests or specific IgE. Children were evaluated for the presence of bronchial asthma, atopic dermatitis, allergic rhinitis. A questionnaire evaluating the occurrence of allergic symptoms in children after contact with the cat and dog was performed. Mothers completed a questionnaire regarding cat exposure: during pregnancy and having a cat at home. A blood sample was taken from all children to measure the level of IL-33 in the serum. RESULTS Keeping a cat in the home, once in the past, or having a cat in the home during the mother's pregnancy, revealed a statistically significant relationship with IL-33 levels in the studied patients. Also, daily contact with a cat during pregnancy affected the level of IL-33. Higher levels of IL-33 were shown in people with hypersensitivity to cat and pollen allergens and cat and other animals. In patients with bronchial asthma higher levels of IL-33 were found than in patients without bronchial asthma. CONCLUSIONS Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children.

中文翻译：

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IL-33与对猫敏感的儿童过敏有关。

背景技术一些研究表明，生命早期接触动物过敏原构成了过敏性致敏发展的相关危险因素。目的本研究的目的是确定白介素-33在对猫过敏原伴有过敏性鼻炎和/或哮喘的儿童中的作用。方法该研究纳入了51名5-18岁的儿童，男女均对猫过敏。通过皮肤点刺试验或特异性IgE确认了对猫过敏原的过敏。对儿童进行了支气管哮喘，特应性皮炎，过敏性鼻炎的评估。进行了调查表，评估了与猫和狗接触后儿童过敏症状的发生情况。母亲们完成了一份关于猫暴露的问卷调查：怀孕期间和在家养猫。从所有儿童那里取血样以测量血清中IL-33的水平。结果过去一次将猫养在家里，或者在母亲怀孕期间将猫养在家里，这与研究患者的IL-33水平具有统计学意义的相关性。另外，怀孕期间每天与猫接触会影响IL-33的水平。在对猫和花粉过敏原以及猫和其他动物过敏的人群中显示出较高的IL-33水平。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。结果过去一次将猫养在家里，或者在母亲怀孕期间将猫养在家里，这与研究患者的IL-33水平具有统计学意义的相关性。另外，怀孕期间每天与猫接触会影响IL-33的水平。在对猫和花粉过敏原以及猫和其他动物过敏的人群中显示出较高的IL-33水平。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。结果过去一次将猫养在家里，或者在母亲怀孕期间将猫养在家里，这与研究患者的IL-33水平具有统计学意义的相关性。另外，怀孕期间每天与猫接触会影响IL-33的水平。在对猫和花粉过敏原以及猫和其他动物过敏的人群中显示出较高的IL-33水平。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。揭示了与研究患者中IL-33水平有统计学意义的关系。另外，怀孕期间每天与猫接触会影响IL-33的水平。在对猫和花粉过敏原以及猫和其他动物过敏的人群中显示出较高的IL-33水平。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。揭示了与研究患者中IL-33水平有统计学意义的关系。另外，怀孕期间每天与猫接触会影响IL-33的水平。在对猫和花粉过敏原以及猫和其他动物过敏的人群中显示出较高的IL-33水平。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。在支气管哮喘患者中，IL-33水平高于无支气管哮喘患者。结论IL-33的血清水平升高与怀孕和幼儿期养猫有关，并且可能与儿童哮喘的发展有关。