Ceruloplasmin (CP) is a mammalian blood plasma ferroxidase. More than 95% of the copper found in plasma is carried by this protein, which is a member of the multicopper oxidase family. Proteins from this group are able to oxidize substrates through the transfer of four electrons to oxygen. The essential role of CP in iron metabolism in humans is particularly evident in the case of loss-of-function mutations in the CP gene resulting in a neurodegenerative syndrome known as aceruloplasminaemia. However, the functions of CP are not limited to the oxidation of ferrous iron to ferric iron, which allows loading of the ferric iron into transferrin and prevents the deleterious reactions of Fenton chemistry. In recent years, a number of novel CP functions have been reported, and many of these functions depend on the ability of CP to form stable complexes with a number of proteins.

中文翻译：

---

寻找伴侣：铜蓝蛋白在蛋白质-蛋白质相互作用中的作用。

铜蓝蛋白（CP）是一种哺乳动物的血浆铁过氧化物酶。血浆中发现的铜中有95％以上是这种蛋白质所携带的，该蛋白质是多铜氧化酶家族的成员。这组蛋白质能够通过将四个电子转移到氧气来氧化底物。CP在人的铁代谢中的基本作用在CP基因的功能丧失突变导致称为神经铜质蛋白血症的神经变性综合征的情况下尤其明显。然而，CP的功能不限于将亚铁氧化为三价铁，这允许将三价铁负载入转铁蛋白并防止芬顿化学的有害反应。近年来，已经报道了许多新颖的CP功能，