Silver catfish (Rhamdia quelen) is a fish species with neotropical distribution, and is a potential model organism to study polluted environment. The aim of this study is to analyze the response of silver catfish to environmental concentrations of waterborne zinc (Zn) over 96 h. Significant metal accumulation was seen in gill, intestine and liver tissues. No significant accumulation was seen in muscle tissue. Lipid peroxidation increased in the brain, and decreased in the muscle and liver at all levels of exposure. Zinc exposure led to decreased protein carbonyl levels in the brain and increased levels in the liver. The activity of catalase in the liver was reduced for all exposed groups. Glutathione S-transferase activity decreased in the brain at the highest level of exposure and in the liver at all Zn concentrations tested. Non-protein thiols increased in the muscle and in the gills after exposure. Ascorbic acid levels increased in the brain and in the gills. Exposure to Zn also altered the metabolic parameters, causing decreased lactate and ammonia levels in the muscle, and decreased glycogen in the liver. Zinc exposure increased ammonia and amino acid levels in the liver, and increase glycogen and amino acid levels in muscle tissue. Our results demonstrate that exposure to environmentally relevant concentrations of Zn led to accumulation of metals in the tissues of silver catfish, with significant changes in biochemical parameters.

中文翻译：

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银cat鱼组织中水性锌的生物累积及其对生化参数的影响。

银cat鱼（Rhamdia quelen）是具有新热带分布的鱼类，是研究污染环境的潜在模式生物。这项研究的目的是分析银cat鱼在96小时内对环境中水性锌（Zn）浓度的响应。在g，肠和肝组织中观察到大量金属积累。在肌肉组织中未观察到明显的积累。在所有暴露水平下，脂质过氧化在大脑中都会增加，而在肌肉和肝脏中则下降。锌暴露导致大脑中蛋白质羰基水平降低，肝脏中蛋白质水平升高。所有暴露组的肝脏中过氧化氢酶的活性均降低。谷胱甘肽S-转移酶活性在最高暴露水平下在大脑中降低，并且在所有测试的锌浓度下在肝脏中均降低。暴露后肌肉和the中的非蛋白质硫醇含量增加。脑和腮中的抗坏血酸水平增加。暴露于锌也会改变代谢参数，导致肌肉中乳酸和氨的含量降低，肝脏中的糖原含量降低。锌暴露会增加肝脏中的氨和氨基酸水平，并增加肌肉组织中的糖原和氨基酸水平。我们的结果表明，与环境相关的Zn暴露会导致银accumulation鱼组织中金属的积累，并且生化参数发生显着变化。并降低肝脏中的糖原。锌暴露会增加肝脏中的氨和氨基酸水平，并增加肌肉组织中的糖原和氨基酸水平。我们的结果表明，与环境相关的Zn暴露会导致银accumulation鱼组织中金属积累，并且生化参数发生显着变化。并降低肝脏中的糖原。锌暴露会增加肝脏中的氨和氨基酸水平，并增加肌肉组织中的糖原和氨基酸水平。我们的结果表明，与环境相关的Zn暴露会导致银accumulation鱼组织中金属积累，并且生化参数发生显着变化。