PURPOSE To compare the central and peripheral (< 2 mm from the limbus) endothelial regions of the human cornea of young contact lens (CL) neophytes, in terms of endothelial cell density (ECD), polymorphism through cell hexagonality (HEX), and polymegethism through the coefficient of variation of cell areas (CoV). MATERIALS AND METHODS In vivo, central, temporal, and nasal ECDs, HEXs, and CoVs were determined for thirty healthy right eyes (age: 22-30 years) using a Takagi 700 G L LED slit-lamp biomicroscope equipped with the centre-dot EndoKer© for the analysis of endothelium images. RESULTS The mean central ECD (2586 ± 233 mm-2) was lower than peripheral ECDs (nasal 2733 ± 225 mm-2, temporal 2674 ± 260 mm-2) (p = 0.03 and p = 0.02, respectively). The mean central HEX (53.0 ± 4.6%) was lower than peripheral HEXs (nasal 57.2 ± 4.3%, temporal 57.1 ± 4.5%) (both p < 0.005), while the mean central CoV (28.2 ± 2.5%) was higher than peripheral CoVs (nasal 25.8 ± 2.2%, temporal 26.1 ± 2.2%) (both p ≤ 0.001). CONCLUSIONS In young healthy non-CL wearers, the peripheral corneal endothelium displays a higher ECD and significantly better cell regularity (higher HEX and lower CoV) compared to the central cornea. A clinical evaluation of the corneal endothelium requires, therefore, a full characterization of the different areas.

中文翻译：

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基于裂隙灯的人角膜内皮的周边区域和中心区域评估。

目的比较新生隐形眼镜（CL）新生人类角膜的中央和周边（距角膜缘<2 mm）内皮细胞区域的内皮细胞密度（ECD），通过细胞六边形的多态性（HEX）和多态性通过细胞面积变异系数（CoV）。材料与方法使用配备有中心点EndoKer的Takagi 700 GL LED裂隙灯生物显微镜，对三十只健康的右眼（年龄：22-30岁）确定体内，中央，颞部和鼻腔的ECD，HEX和CoV。 ©用于分析内皮细胞图像。结果平均中央ECD（2586±233 mm-2）低于周围ECD（鼻2733±225 mm-2，颞侧2674±260 mm-2）（分别为p = 0.03和p = 0.02）。平均中央HEX（53.0±4.6％）低于周围HEX（鼻57.2±4.3％，颞部57）。1±4.5％）（均p <0.005），而平均中心CoV（28.2±2.5％）高于周围CoVs（鼻25.8±2.2％，颞26.1±2.2％）（均p≤0.001）。结论在年轻健康的非CL佩戴者中，与中央角膜相比，外周角膜内皮显示出更高的ECD和明显更好的细胞规则性（更高的HEX和更低的CoV）。因此，对角膜内皮的临床评估需要对不同区域进行全面表征。