Iron-sulfur (Fe-S) clusters are considered one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe-S clusters can act as redox sensors or catalysts and are found to be used by a large number of functional and structurally diverse proteins. Here, we cover current knowledge of the SUF multiprotein machinery that synthesizes and inserts Fe-S clusters into proteins. Specific focus is put on the ABC ATPase SufC, which contributes to building Fe-S clusters, and appeared early on during evolution.

中文翻译：

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SUF系统：在Fe-S簇生物发生中起作用的ABC ATPase依赖性蛋白复合物。

铁-硫（Fe-S）团簇被认为是存在于生命的三个域中的最古老，用途最广泛的无机辅因子之一。Fe-S团簇可以充当氧化还原传感器或催化剂，并被大量功能和结构上多样化的蛋白质所使用。在这里，我们涵盖了SUF多蛋白机制的最新知识，该机制可以合成Fe-S簇并将其插入蛋白质中。特别关注的是ABC ATPase SufC，它有助于构建Fe-S团簇，并在进化过程的早期出现。