The mechanisms underlying cell and organ dysfunctions in hypertension are uncertain. The spontaneously hypertensive rat (SHR) has elevated levels of unchecked degrading proteases compared to the control Wistar Kyoto (WKY) rat. The extracellular proteases destroy membrane receptors leading to cell dysfunctions, including arteriolar constriction and elevated blood pressure. Our goal was to identify potential sources of the uncontrolled enzymatic activity.

中文翻译：

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自发性高血压大鼠胰腺蛋白酶活性的来源及其在临时禁食期间的降低。

高血压中细胞和器官功能障碍的潜在机制尚不确定。与对照Wistar Kyoto（WKY）大鼠相比，自发性高血压大鼠（SHR）的未经检查的降解蛋白酶水平升高。细胞外蛋白酶破坏膜受体，导致细胞功能障碍，包括小动脉收缩和血压升高。我们的目标是确定不受控制的酶活性的潜在来源。