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Suspected adverse effects after human papillomavirus vaccination: a temporal relationship.
Immunologic Research ( IF 3.3 ) Pub Date : 2019-02-06 , DOI: 10.1007/s12026-018-9063-y
Shu-Ichi Ikeda 1 , Akiyo Hineno 1, 2 , Kazuki Ozawa 2 , Tomomi Kinoshita 2
Affiliation  

In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalities in laboratory test results. Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Our study has shown that the period of HPV vaccination considerably overlapped with that of unique postvaccination symptom development, adding that new patients with possible HPV vaccine-related symptoms have not appeared during our recent 28-month follow-up period. This social episode has now subsided in Japan.

中文翻译:

人乳头瘤病毒疫苗接种后可疑的不良反应:暂时的关系。

在日本,许多青春期女孩在接受人乳头瘤病毒(HPV)疫苗接种后抱怨症状异常,并且由于缺乏病理学发现,放射影像学和实验室检查结果中的特定异常,其中大多数最初被诊断出患有精神疾病。 。后来,这些症状被认为是HPV疫苗接种后的不良反应,日本公共卫生,劳工和福利部在4年零9个月前撤消了HPV疫苗接种的建议。但是,尚未证明HPV疫苗接种与这些症状的发展之间存在因果关系。我们的研究表明,HPV疫苗接种的时间与独特的疫苗接种后症状发展的时间重叠,补充说,在我们最近的28个月的随访期内,没有出现可能与HPV疫苗相关的症状的新患者。该社交事件现已在日本消退。
更新日期:2019-11-01
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