Psychoactive pharmaceuticals release into the environment and reach humans through a variety of routes, including sewage, drinking water, contaminated irrigation water, biosolids, soil and food. It was assumed that these compounds via the environment could induce genetic effects in the etiology of human neurological disorders. With the help of in vitro, in vivo and in silico approaches, we demonstrated that psychoactive pharmaceuticals in drinking water can cross maternal biological barriers and alter in vitro molecular and genetic mechanisms that potentially have a key role in the development, growth and regulation of neuronal systems during embryonic brain development.

中文翻译：

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环境中精神活性药物与人类神经系统疾病的潜在关联。

精神活性药物通过各种途径释放到环境中并到达人类，包括污水，饮用水，受污染的灌溉水，生物固体，土壤和食物。据推测，这些化合物通过环境可以在人类神经系统疾病的病因中诱导遗传作用。在体外，体内和计算机模拟方法的帮助下，我们证明了饮用水中的精神活性药物可以跨越母亲的生物障碍，并改变可能在神经元的发育，生长和调节中发挥关键作用的体外分子和遗传机制。胚胎脑发育过程中的系统。