Abstract

Under conditions of the experimental model of Parkinson’s disease at the preclinical (early) and clinical stage—injection of mice with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 5 and 10 weeks—the toxic effects of MPTP was evaluated (the content of catecholamines and their metabolites in the heart, which receives the most extensive sympathetic innervation, was determined). The obtained data indicated the beginning of desympathization of the heart at the preclinical stage of PD and its progression at the clinical stage of the disease.

中文翻译：

---

估算周围器官中的儿茶酚胺的代谢，作为其在神经毒素影响下的去交感的指标。

摘要

在临床前（早期）和临床阶段的帕金森氏病实验模型的条件下，给小鼠注射神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）5周和10周-评估了MPTP的毒性作用（确定了心脏中儿茶酚胺及其代谢物的含量，该含量受到最广泛的交感神经支配）。所获得的数据表明，在PD的临床前阶段开始对心脏进行去交感，并在疾病的临床阶段进行。