BACKGROUND Differential diagnosis between acute-phase Zika and dengue is challenging because of a similar clinical presentation and the lack of available molecular diagnosis tools in most of endemic areas. OBJECTIVES Our study aimed to evaluate the use of simple laboratory parameters to differentiate these infections. METHODS We retrospectively compared simple hematology and biochemistry values in 81 and 341 patients with confirmed Zika and dengue, respectively, collected from June 2013 to March 2014 during the French Polynesia outbreaks. RESULTS Thrombocytopenia, neutropenia, leukopenia, lymphopenia, and elevated aspartate aminotransaminases were significantly more frequent in dengue than in Zika (p < 0.001). Platelets <100 × 109/L, neutrophils <0.5 × 109/L, lymphocytes <0.5 × 109/L, and aspartate aminotransaminases >100 IU/mL were found in dengue but not in Zika. The positive predictive value of the -association of leukocytes <4 × 109/L + lymphocytes <1 × 109/L + aspartate aminotransaminases >40 IU/mL for the diagnosis of dengue was 90%, with an accuracy of 82.4%. CONCLUSION For the differential diagnosis between acute-phase Zika and dengue, there is no specific standard laboratory pattern. We identified cutoff values and a combination of laboratory parameters that are a strong argument against Zika and in favor of dengue.

中文翻译：

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在急性寨卡病毒和登革热病毒的鉴别诊断中使用简单的实验室参数。

背景技术由于相似的临床表现以及在大多数流行地区缺乏可用的分子诊断工具，在急性期寨卡病毒和登革热之间的鉴别诊断具有挑战性。目的我们的研究旨在评估使用简单的实验室参数来区分这些感染。方法我们回顾性比较了2013年6月至2014年3月法属波利尼西亚爆发期间确诊的寨卡病毒和登革热的81例和341例简单血液学和生化值。结果登革热中的血小板减少症，中性粒细胞减少症，白细胞减少症，淋巴细胞减少症和天冬氨酸氨基转氨酶升高的发生率明显高于Zika（p <0.001）。血小板<100×109 / L，中性粒细胞<0.5×109 / L，淋巴细胞<0.5×109 / L和天冬氨酸氨基转氨酶> 在登革热中发现了100 IU / mL，但在寨卡病毒中却未发现。白细胞<4×109 / L +淋巴细胞<1×109 / L +天冬氨酸氨基转氨酶> 40 IU / mL的联合诊断对登革热的阳性预测值为90％，准确度为82.4％。结论对于急性期寨卡病毒和登革热的鉴别诊断，没有特定的标准实验室模式。我们确定了临界值和实验室参数的组合，这是反对Zika并支持登革热的有力论据。没有特定的标准实验室模式。我们确定了临界值和实验室参数的组合，这是反对Zika并支持登革热的有力论据。没有特定的标准实验室模式。我们确定了临界值和实验室参数的组合，这是反对Zika并支持登革热的有力论据。