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Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial
Clinical EEG and Neuroscience ( IF 1.6 ) Pub Date : 2019-07-15 , DOI: 10.1177/1550059419863209
Elham Sharafi 1 , Arsia Taghva 2 , Mohammad Arbabi 1 , Afsaneh Dadarkhah 3 , Jamshid Ghaderi 4
Affiliation  

In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds ramp-up from 0 and 30 seconds ramp-down. For the sham group we administered 30 seconds ramp-up to 2 mA, 10 seconds stimulation, 30 seconds ramp-down, and 20 minutes no current. The anode was fixed on the center of F3, and the cathode on F4, over the dorsolateral prefrontal cortex. We assessed the Hamilton Depression Rating Scale at the baseline (mean difference = 1.0, P = .630), at the last session of tDCS, and at 1-month postintervention. There were statistically significant differences in the mean Hamilton scores after the intervention, and 1 month later in favor of active group; P < .001, and P = .003, respectively. Mixed analysis of variance showed a significant difference in the mean scores for active group P = .010 and pattern of change during the study P < .001 in favor of active intervention. We concluded that tDCS is an efficient therapy for patients with resistant major depression, and the benefits would remain at least for 1 month.

中文翻译:

经颅直流电刺激治疗难治性重度抑郁症:一项双盲随机假对照试验

在目前的研究中,我们试图评估经颅直流电刺激 (tDCS) 对难治性重性抑郁症的影响。我们在大学医院进行了一项双盲随机假对照试验。招募了在用选择性血清素再摄取抑制剂治疗 8 周后抑郁强度降低小于 50% 的个体。平均 (SD) 年龄为 47.2 (12.0) 岁的三十名患者(16 名女性)被随机分配到 2 组。对于活跃组,我们在每个会话中进行 20 分钟的 2-mA 刺激,从 0 秒开始上升 30 秒,下降 30 秒。对于假手术组,我们进行 30 秒升至 2 mA、10 秒刺激、30 秒缓降和 20 分钟无电流。阳极固定在 F3 的中心,阴极固定在 F4 上,在背外侧前额叶皮层上。我们在基线(平均差 = 1.0,P = .630)、tDCS 的最后一次会议和干预后 1 个月评估了汉密尔顿抑郁量表。干预后汉密尔顿平均得分有统计学显着差异,1个月后有利于活动组;P < .001 和 P = .003,分别。混合方差分析显示,积极干预组的平均得分存在显着差异,P = .010,研究期间的变化模式 P < .001,有利于积极干预。我们得出的结论是,tDCS 是治疗难治性重性抑郁症患者的有效疗法,其益处至少会持续 1 个月。在 tDCS 的最后一次会议和干预后 1 个月。干预后汉密尔顿平均得分有统计学显着差异,1个月后有利于活动组;P < .001 和 P = .003,分别。混合方差分析显示,积极干预组的平均得分存在显着差异,P = .010,研究期间的变化模式 P < .001,有利于积极干预。我们得出的结论是,tDCS 是治疗难治性重性抑郁症患者的有效疗法,其益处至少会持续 1 个月。在 tDCS 的最后一次会议和干预后 1 个月。干预后汉密尔顿平均得分有统计学显着差异,1个月后有利于活动组;P < .001 和 P = .003,分别。混合方差分析显示,积极干预组的平均得分存在显着差异,P = .010,研究期间的变化模式 P < .001,有利于积极干预。我们得出的结论是,tDCS 是治疗难治性重性抑郁症患者的有效疗法,其益处至少会持续 1 个月。混合方差分析显示,积极干预组的平均得分存在显着差异,P = .010,研究期间的变化模式 P < .001,有利于积极干预。我们得出的结论是,tDCS 是治疗难治性重性抑郁症患者的有效疗法,其益处至少会持续 1 个月。混合方差分析显示,积极干预组的平均得分存在显着差异,P = .010,研究期间的变化模式 P < .001,有利于积极干预。我们得出的结论是,tDCS 是治疗难治性重性抑郁症患者的有效疗法,其益处至少会持续 1 个月。
更新日期:2019-07-15
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