Pathogenesis and the development of Alzheimer's disease (AD) are subject to several environmental and genetic factors. This study was aimed to estimate the frequency of mutations in leucine-rich repeat kinase 2 (LRRK2) gene to examine the association between these mutations and risk of AD. For finding the articles, four databases including PubMed, Web of Science, Scopus, and Cochrane Library were checked up to August 2018. An analysis was done by RevMan 5.3 using crude odds ratio (OR) and 95% confidence intervals (CIs) to determine the association between LRRK2 polymorphisms and the risk of AD. Of 359 articles identified in the databases, 13 studies were included and analysed in the meta-analysis. There was no significant risk of AD related to five LRRK2 polymorphisms (rs33949390, rs34778348, rs7308720, rs34637584, and rs35870237). The results showed that LRRK2 variants (p.R1628P, p.G2385R, p.N551K, p.G2019S, and p.I2020T) were not associated with the risk of AD and were not a common cause of AD in populations. Nevertheless, p.R1628P can be examined in patients with AD in other populations in the future studies.

中文翻译：

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阿尔茨海默氏病中富含亮氨酸的重复激酶2（LRRK2）多态性的荟萃分析。

阿尔茨海默氏病（AD）的发病机理和发展受多种环境和遗传因素的影响。这项研究旨在估计富含亮氨酸的重复激酶2（LRRK2）基因突变的频率，以检查这些突变与AD风险之间的关联。为了查找这些文章，截止到2018年8月，已检查了包括PubMed，Web of Science，Scopus和Cochrane Library在内的四个数据库。RevMan5.3使用原始比值比（OR）和95％置信区间（CI）进行了分析，以确定LRRK2多态性与AD风险之间的关联。在数据库中鉴定的359篇文章中，纳入了13项研究并在荟萃分析中进行了分析。没有与5个LRRK2多态性（rs33949390，rs34778348，rs7308720，rs34637584和rs35870237）相关的AD显着风险。结果表明，LRRK2变体（p.R1628P，p.G2385R，p.N551K，p.G2019S和p.I2020T）与AD风险无关，也不是人群中常见的AD原因。尽管如此，在以后的研究中仍可以在其他人群的AD患者中检查p.R1628P。