ABSTRACT Aluminum (Al) is a neurotoxic substance which has played an important role in the etiology, pathogenesis, and development of amyloid-β (Aβ) plaques. This study was carried out to evaluate the neuroprotective effect of aqueous cinnamon extract against aluminum chloride (AlCl3)-induced Alzheimer’s disease. Forty adult male albino rats, randomly divided into four equal groups. Control group; ACE200 group administered aqueous cinnamon extract (ACE) orally; AlCl3 group received daily intraperitoneal (i.p.) injection of AlCl3 for 60 days to induce neurotoxicity and AlCl3 + ACE200 group received a combination of AlCl3 and ACE in the same dose and route as previous groups. Aluminum administration significantly enhanced the memory impairment and the Aβ formation in the rat model. The cerebellum exhibited a significant reduced number of Purkinje cells, marked decrease in the density of dendritic arborization and prominent perineuronal spaces in the molecular layer. There was loss of dendritic spines, neurofibrillary degeneration, and appearance of neuritic plaques. Concomitant administration of AlCl3 and ACE displayed an observable protection against these changes with progressive improvement in memory and intellectual performance. In conclusion, ACE may play a protective role against formation of amyloid-β plaques in cerebellum.

中文翻译：

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肉桂醛对铝诱导阿尔茨海默病大鼠模型的神经改善作用

摘要 铝 (Al) 是一种神经毒性物质，在淀粉样蛋白 β (Aβ) 斑块的病因、发病机制和发展中起重要作用。本研究旨在评估肉桂水提取物对氯化铝 (AlCl3) 诱导的阿尔茨海默病的神经保护作用。四十只成年雄性白化鼠，随机分成四等份。控制组; ACE200组口服肉桂提取物（ACE）；AlCl3 组接受每日腹腔 (ip) 注射 AlCl3 60 天以诱导神经毒性，AlCl3 + ACE200 组以与前组相同的剂量和途径接受 AlCl3 和 ACE 的组合。铝给药显着增强了大鼠模型中的记忆障碍和 Aβ 形成。小脑表现出浦肯野细胞数量显着减少，分子层中树突状树枝化和突出的神经元周围空间的密度显着降低。有树突棘丢失、神经原纤维变性和神经炎斑块的出现。AlCl3 和 ACE 的同时给药显示出可观察到的针对这些变化的保护作用，并逐渐改善了记忆力和智力表现。总之，ACE可能对小脑中β淀粉样蛋白斑块的形成起到保护作用。AlCl3 和 ACE 的同时给药显示出可观察到的针对这些变化的保护作用，并逐渐改善了记忆力和智力表现。总之，ACE可能对小脑中β淀粉样蛋白斑块的形成起到保护作用。AlCl3 和 ACE 的同时给药显示出可观察到的针对这些变化的保护作用，并逐渐改善了记忆力和智力表现。总之，ACE可能对小脑中β淀粉样蛋白斑块的形成起到保护作用。