In the past 20 years, zebrafish has gradually become an important animal model for studying the function of human genes. At the same time, identification of zebrafish reference genome sequences and >10,000 protein-coding genes indicates that they are at least 75% homologous to human genes, further validating its utility as a research model for growth and developments (GDs). However, the molecular mechanism of zebrafish GDs has almost no molecular interactions, so a protein–protein interaction (PPI) network is highly desirable. The project extracted 58 genes on the fifth chromosome of the model organism, and studied and modeled its GDs mechanisms, which encompassed 296 interactions between the 58 proteins involved in GDs. This includes not only accurate predictions of PPI but also those molecular interactions collected from the literature and experimentally derived. These molecules then interact, modularize, look for central genes, analyze, and predict their GDs processes, and hope to help scholars study the process of GDs, providing hypotheses and help.

中文翻译：

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斑马鱼第五染色体的蛋白质网络分析。

在过去的20年中，斑马鱼已逐渐成为研究人类基因功能的重要动物模型。同时，鉴定斑马鱼参考基因组序列和> 10,000个蛋白质编码基因表明它们与人类基因至少75％同源，进一步证实了其作为生长发育研究模型（GDs）的效用。但是，斑马鱼GDs的分子机制几乎没有分子相互作用，因此非常需要蛋白质-蛋白质相互作用（PPI）网络。该项目从模型有机体的第五条染色体上提取了58个基因，并对其GDs机制进行了研究和建模，其中包括GDs所涉及的58种蛋白质之间的296种相互作用。这不仅包括对PPI的准确预测，还包括从文献中收集并通过实验得出的那些分子相互作用。这些分子然后相互作用，模块化，寻找中心基因，分析和预测其GDs过程，并希望帮助学者研究GDs的过程，提供假设和帮助。