In this study, we produced curcumin loaded gelatine microparticles, through spray-drying method, with dialdehyde carboxymethyl cellulose (DCMC) which is introduced as a new cross-linking agent for drug delivery systems and examined toxicities by comparison of traditional cross-linking agents. We employed various parameters in the production and tried to develop the most efficient drug delivery system through Taguchi method by examining efficiencies on gastric cancer under in vitro conditions. The results indicated gelatine microparticles cross-linked with DCMC offers more biocompatible drug delivery systems. The particle size of the microparticles produced via different parameters varies from 1.926 to 3.357 µm. Curcumin was substantially remained stable after 6 months. This study indicates potential use of DCMC cross-linked gelatine microparticles as drug delivery vehicle.

在这项研究中，我们通过喷雾干燥法生产了含有姜黄素的明胶微粒，并用二醛羧甲基纤维素（DCMC）作为药物递送系统的新型交联剂而引入，并通过比较传统交联剂来检查毒性。我们在生产中采用了各种参数，并尝试通过田口方法研究体外条件下对胃癌的疗效，从而开发出最有效的药物递送系统。结果表明，与DCMC交联的明胶微粒提供了更具生物相容性的药物递送系统。通过产生的微粒的粒径不同的参数从1.926到3.357 µm不等。姜黄素在6个月后基本保持稳定。这项研究表明，DCMC交联的明胶微粒可作为药物输送载体。