Epigenetic and posttranslational modifications have been proved to participate in multiple cellular processes and suggested to be an important regulatory mechanism on transcription of genes in eukaryotes. However, our knowledge about epigenetic and posttranslational modifications mainly comes from the studies of yeasts, plants, and animals. Recently, epigenetic and posttranslational modifications have also raised concern for the relevance of regulating fungal biology in Aspergillus. Emerging evidence indicates that these modifications could be a connection between genetic elements and environmental factors, and their combined effects may finally lead to fungal phenotypical changes. This article describes the advances in typical DNA and protein modifications in the genus Aspergillus, focusing on methylation, acetylation, phosphorylation, ubiquitination, sumoylation, and neddylation.

已证明表观遗传和翻译后修饰可参与多种细胞过程，并被认为是真核生物中基因转录的重要调控机制。但是，我们对表观遗传学和翻译后修饰的认识主要来自酵母，植物和动物的研究。最近，表观遗传学和翻译后修饰也引起人们对曲霉菌中真菌生物学调控的相关性的关注。越来越多的证据表明，这些修饰可能是遗传因素与环境因素之间的联系，它们的综合作用最终可能导致真菌的表型改变。本文介绍了曲霉属中典型的DNA和蛋白质修饰的进展，着重于甲基化，乙酰化，磷酸化，泛素化，SUMO化和炔化。