Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors such as the estrogen receptor and the androgen receptor and several other transcription factors to enhance their effects on target gene expression. SRC-3 plays important roles in many developmental, physiological, and pathologic events, including body growth, mammary gland development, energy homeostasis, inflammatory regulation, and cancer initiation and progression. SRC-3 has been suggested to be involved in host defense against bacterial pathogens. In this review, we summarize the roles of SRC-3 in host defense against peritoneal and enteric bacterial infection and discuss the potential clinical implications.

中文翻译：

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类固醇受体共激活剂3在宿主防御细菌病原体中的作用。

类固醇受体共激活因子3（SRC-3）是一种转录共激活因子，可与核受体（如雌激素受体和雄激素受体）以及其他几种转录因子相互作用，以增强其对靶基因表达的作用。SRC-3在许多发育，生理和病理事件中起重要作用，包括身体生长，乳腺发育，能量稳态，炎症调节以及癌症的发生和发展。已建议SRC-3参与宿主对细菌病原体的防御。在这篇综述中，我们总结了SRC-3在宿主防御腹膜和肠道细菌感染中的作用，并讨论了潜在的临床意义。