Regulatory effects of γδ T-cells on immune responses have been studied for years. We have investigated the regulatory effect of γδ T-cells on Th1 and Th17 autoimmune responses, and have studied molecular and cellular mechanisms by which γδ T-cells enhance or inhibit immune responses, exploiting a well-characterized murine model of experimental autoimmune uveitis (EAU). Our results show that (1) aberrant γδ T-cell activation is an important pathogenic event in EAU; (2) γδ T-cells have a unique regulatory effect on Th17 autoimmune responses, which is shaped by the activation status of γδ T-cells; and (3) γδ-mediated immunoregulation is closely linked with the extracellular adenosine metabolism. Reciprocal interactions between γδ T-cells and extracellular adenosine partially determine the development of EAU.

中文翻译：

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γδ T 细胞和腺苷介导的免疫调节在实验性自身免疫性葡萄膜炎发病机制中的联系。


γδ T 细胞对免疫反应的调节作用已被研究多年。我们研究了 γδ T 细胞对 Th1 和 Th17 自身免疫反应的调节作用，并研究了 γδ T 细胞增强或抑制免疫反应的分子和细胞机制，利用了良好表征的实验性自身免疫性葡萄膜炎 (EAU) 小鼠模型）。我们的研究结果表明：（1）γδ T 细胞异常激活是 EAU 的重要致病事件； (2) γδ T细胞对Th17自身免疫反应具有独特的调节作用，这种调节作用是由γδ T细胞的激活状态决定的； (3)γδ介导的免疫调节与细胞外腺苷代谢密切相关。 γδ T 细胞和细胞外腺苷之间的相互作用部分决定了 EAU 的发展。