Abstract Objective: There is a lack of empirical knowledge on how different comorbid disorders and symptoms change in the course of initial abstinence and withdrawal. The aim of this study is to replicate previous findings on the symptom course using a larger sample and up-to-date psychometric instruments. Methods: During inpatient alcohol detoxification, we measured comorbid depression (Beck Depression Inventory second revision; BDI-II) and posttraumatic stress disorder (PTSD Checklist for DSM-5; PCL-5) symptoms twice among 87 participants within a 10-day interval. Results: Significant decreases occurred for symptoms of reexperiencing (p < .001, d = .27), avoidance (p < .001, d = .41), negative cognitions (p = .03, d = .22), alteration in arousal (p < .001, d = .37), and the PCL-5 total score (p < .001, d = .35). Depression scores also significantly declined with a greater effect size (p < .001, d = .53). Depression screening was not stable, while posttraumatic stress disorder screening was revealed to be stable through alcohol detoxification. Interaction effects were detected, indicating the higher symptom decrease for patients who initially had positive posttraumatic stress disorder and depression screenings, F(1, 84) = 23.01, p < .001 and F(1, 84) = 10.01, p < .01, respectively. Conclusions: Patients in the first stage of alcohol treatment show high levels of comorbid psychopathology. These symptoms change during detoxification, especially for patients having a higher initial symptomatic burden. More research is needed to guide practitioners to make reliable comorbid diagnoses in this early treatment phase as this can motivate patients to pursue subsequent treatments.

中文翻译：

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酒精解毒治疗期间自我报告的PTSD和抑郁症状的变化

摘要 目的：对于不同的共存疾病和症状在初始戒断和戒断过程中如何变化，缺乏经验知识。本研究的目的是使用更大的样本和最新的心理测量仪器来复制先前在症状过程中的发现。方法：在住院酒精戒毒期间，我们在 10 天的间隔内两次测量了 87 名参与者的共患抑郁症（贝克抑郁量表第二次修订；BDI-II）和创伤后应激障碍（DSM-5 的 PTSD 检查表；PCL-5）症状。结果：重新体验 (p < .001, d = .27)、回避 (p < .001, d = .41)、消极认知 (p = .03, d = .22)、唤醒（p < .001，d = .37）和 PCL-5 总分（p < .001，d = .35）。随着效应量的增加，抑郁评分也显着下降（p < .001，d = .53）。抑郁症筛查不稳定，而创伤后应激障碍筛查则通过酒精解毒显示稳定。检测到交互作用，表明最初患有创伤后应激障碍和抑郁症筛查阳性的患者的症状减轻程度更高，F(1, 84) = 23.01, p < .001 和 F(1, 84) = 10.01, p < .01 ， 分别。结论：处于酒精治疗第一阶段的患者表现出高水平的共病精神病理学。这些症状在解毒过程中会发生变化，尤其是对于初始症状负担较高的患者。