Arteriolargenesis can be induced by concomitant stimulation of nitric Oxide (NO)‐Angiopoietin receptor (Tie)‐Vascular Endothelial Growth Factor (VEGF) signaling in the rat mesentery angiogenesis assay. We hypothesized that the same combination of exogenously added growth factors would also have a positive impact on arteriolargenesis and, consequently, the recovery of blood flow in a model of unilateral hindlimb ischemia.

中文翻译：

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在外周缺血小鼠模型中，增强的Notch信号传导可响应一氧化氮-血管生成素信号调节非生产性血运重建。


在大鼠肠系膜血管生成测定中，一氧化氮 (NO)-血管生成素受体 (Tie)-血管内皮生长因子 (VEGF) 信号传导的同时刺激可诱导动脉生成。我们假设外源添加的生长因子的相同组合也会对动脉生成产生积极影响，从而对单侧后肢缺血模型中的血流恢复产生积极影响。