Aim. This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) induced ulcerative colitis (UC) in mice in comparison with 6-thioguanine (6-TG), an immune-suppressant chemotherapeutic medicine used for treatment of ulcerative colitis. Material & Methods. Thirty-six adult, male and female BALB/c mice were randomly divided into six groups: group 1 (control negative) not exposed to DSS and did not receive any treatment, group 2 (control positive) exposed to DSS but did not receive any treatment, group 3 exposed to DSS and treated by 0.1 mg/kg of 6-thioguanine, and groups 4, 5, and 6 exposed to DSS and treated by 10, 20, and 40 mg/kg b.w. Shogaol, respectively. At day 56, the mice were checked for their disease activity index (DAI) and they were sacrificed. The colons of the mice were examined for length measurement, histological index score, and the expression of CD133 and CD34 stem cell markers. Results. Shogaol showed a better curative effect than did 6-TG in repairing the colonic mucosal damages in DSS-exposed mice as indicated by the levels of CD133 and CD34 expression in the colonic crypts and by the DAI score, colon length measurements, & histological index score which were significantly reduced in mice treated by Shogaol, particularly the 20 and 40 mg/kg BW doses. Conclusion. The results of this study indicated that oral treatment with the ginger-derived substance Shogaol could be better than the conventional immunosuppressive chemotherapeutic remedy 6-TG in treatment of DSS-induced UC.

中文翻译：

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姜烯酚对 BALB/c 小鼠实验性结肠炎肠干细胞标志物表达的影响。

目标。本研究旨在研究姜的酚类成分姜烯酚与免疫抑制剂 6-硫鸟嘌呤 (6-TG) 相比对葡聚糖硫酸钠 (DSS-) 诱导的小鼠溃疡性结肠炎 (UC) 的影响用于治疗溃疡性结肠炎的化疗药物。材料与方法. 将 36 只成年、雄性和雌性 BALB/c 小鼠随机分为 6 组：第 1 组（对照阴性）未暴露于 DSS 且未接受任何治疗，第 2 组（对照阳性）暴露于 DSS 但未接受任何治疗处理，第 3 组暴露于 DSS 并用 0.1 mg/kg 6-硫鸟嘌呤处理，第 4、5 和 6 组分别暴露于 DSS 并用 10、20 和 40 mg/kg bw 姜烯酚处理。在第 56 天，检查小鼠的疾病活动指数 (DAI) 并将它们处死。检查小鼠结肠的长度测量、组织学指数评分以及 CD133 和 CD34 干细胞标志物的表达。结果. 从结肠隐窝中 CD133 和 CD34 的表达水平以及 DAI 评分、结肠长度测量值和组织学指数评分表明，姜烯酚在修复 DSS 暴露小鼠的结肠粘膜损伤方面显示出比 6-TG 更好的疗效在用姜烯酚处理的小鼠中，尤其是 20 和 40 mg/kg BW 剂量显着降低。结论。本研究结果表明，口服姜衍生物质姜烯酚在治疗 DSS 诱导的 UC 方面优于常规免疫抑制化疗药物 6-TG。