Abstract

Lantana camara Linn. (Verbenaceae) is used traditionally for its numerous medicinal properties such as antimalarial, antibacterial, anticancer and anti-inflammatory. In the present study, we investigated the chemical composition of essential oil from the leaves of L. camara (LCEO) occurring in the Republic of Benin (West Africa) in comparison with LCEOs from other regions; evaluated its sedative effects in mice via inhalation administration; and identified the compounds responsible for activity. LCEO was extracted by hydrodistillation and chemical analyses of the oil were performed by GC and GC/MS. The oil was dominated by monoterpene hydrocarbons (60.58%) and oxygenated monoterpenes (33.39%), among which sabinene (38.81%) and 1,8-cineole (28.90%) were the most abundant. LCEO administered via inhalation to mice significantly decreased locomotor activity in a dose-dependent manner, mainly at the doses of 0.0004 and 0.04 mg per 400 μL of triethyl citrate (TEC). The oil was fractionated to give two fractions, which were further investigated, and revealed that both sabinene and 1,8-cineole were the principal active compounds. The results of the present study indicated that via inhalation administration, LCEO and its main constituents could be considered as promising candidates for the management of dementia, insomnia, attention deficit hyperactivity disorder and other central nervous system-associated diseases.

Graphic abstract

中文翻译：

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通过在小鼠体内吸入，在贝宁共和国出现的马tana丹（Lantana camara）叶中的精油的镇静作用。

摘要

马tana丹（Lantana camara） Linn。（马鞭草科）传统上因其众多的医学特性而被使用，例如抗疟疾，抗菌，抗癌和抗炎。在本研究中，我们调查了来自L. camara叶的精油的化学成分（LCEO）与其他地区的LCEO相比出现在贝宁共和国（西非）；通过吸入给药评估其对小鼠的镇静作用；并鉴定出负责活性的化合物。通过水蒸馏法提取LCEO，并通过GC和GC / MS进行油的化学分析。该油以单萜烃（60.58％）和含氧单萜（33.39％）为主，其中do烯（38.81％）和1,8-桉树脑（28.90％）含量最高。通过吸入给小鼠施用的LCEO以剂量依赖的方式显着降低了运动活性，主要是每400μL柠檬酸三乙酯（TEC）的剂量为0.0004和0.04 mg。将该油分馏，得到两个馏分，将其进行进一步研究，结果表明，sa烯和1 8-桉树脑是主要的活性化合物。本研究的结果表明，通过吸入给药，LCEO及其主要成分可以被认为是治疗痴呆，失眠，注意力缺陷多动障碍和其他中枢神经系统相关疾病的有前途的候选者。

图形摘要