Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles.

中文翻译：

---

皮肤利什曼病新药和治疗方法的发现和临床前开发路线图。

尽管在内脏利什曼病 (VL) 的治疗方面取得了重大进展，并且目前针对这种利什曼病表现的几种新型化合物正处于临床前和临床开发阶段，但用于治疗内脏利什曼病的药物研发 (R & D) 进展有限。皮肤利什曼病 (CL)。在这里，我们回顾了对 CL 新疗法的需求，描述了过去十年中为建立 CL 新药的发现和临床前开发途径而采取的体外和体内测定、模型和方法。这些最新进展包括使用生物发光利什曼原虫的新型小鼠感染模型、皮肤感染的 PK/PD 方法的引入，以及明确的临床前候选者概况。