Frequent air travelers and airplane pilots may develop various types of illnesses. The environmental risk factors associated with air travel syndromes (ATS) or air travel-related adverse health outcomes raised concerns and need to be assessed in the context of risk management and public health. Accordingly, the aim of the present review was to determine ATS, risk factors, and mechanisms underlying ATS using scientific data and information obtained from Medline, Toxline, and regulatory agencies. Additional information was also extracted from websites of organizations, such as the International Air Transport Association (IATA), International Association for Medical Assistance to Travelers (IAMAT), and International Civil Aviation Organization (ICAO). Air travelers are known to be exposed to environmental risk factors, including circadian rhythm disruption, poor cabin air quality, mental stress, high altitude conditions, hormonal dysregulation, physical inactivity, fatigue, biological infections, and alcoholic beverage consumption. Consequences of ATS attributed to air travel include sleep disturbances (e.g., insomnia), mental/physical stress, gastrointestinal disorders, respiratory diseases, circulatory-related dysfunction, such as cardiac arrest and thrombosis and, at worst, mechanical and terrorism-related airplane crashes. Thus safety measures in the cabin before or after takeoff are undertaken to prevent illnesses or accidents related to flight. In addition, airport quarantine systems are strongly recommended to prepare for any ultimate adverse circumstances. Routine monitoring of environmental risk factors also needs to be considered. Frequently, the mechanisms underlying these adverse manifestations involve free radical generation. Therefore, antioxidant supplementation may help to reduce or prevent adverse outcomes by mitigating health risk factors associated with free radical generation.

中文翻译：

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通过抗氧化剂对参与空中旅行综合症的自由基进行风险管理。

频繁的航空旅行者和飞机驾驶员可能会患上各种类型的疾病。与航空旅行综合征（ATS）或与航空旅行相关的不良健康后果相关的环境风险因素引起了人们的关注，需要在风险管理和公共卫生的背景下进行评估。因此，本综述的目的是使用从Medline，Toxline和监管机构获得的科学数据和信息来确定ATS，风险因素和ATS潜在的机制。还从组织的网站（如国际航空运输协会（IATA），国际旅行者医疗援助协会（IAMAT）和国际民航组织（ICAO））的网站中提取了更多信息。众所周知，航空旅行者会受到环境风险因素的影响，包括昼夜节律紊乱，机舱空气质量差，精神压力，高海拔条件，荷尔蒙失调，身体不活动，疲劳，生物感染和饮用酒精饮料。空中旅行引起的空中交通服务的后果包括睡眠障碍（例如失眠），精神/身体压力，胃肠道疾病，呼吸系统疾病，与循环有关的功能障碍，例如心脏骤停和血栓形成，最糟糕的是与机械和恐怖主义有关的飞机失事。因此，在起飞之前或之后采取机舱安全措施以防止与飞行有关的疾病或事故。此外，强烈建议机场隔离系统为任何最终不利情况做准备。还需要考虑对环境危险因素的常规监测。经常，这些不良表现的潜在机制涉及自由基的产生。因此，补充抗氧化剂可以通过减轻与自由基产生有关的健康风险因素来帮助减少或预防不良后果。