BACKGROUND Previous studies indicated inverse relationships between body mass index (BMI), diabetes and prostate-specific antigen (PSA) concentration besides an established positive relationship between age and PSA. Other causal relationships between clinical parameters including hypertension, hepatic function, tests, lipid profile and PSA were also suggested. Thus, we incorporated these parameters all together into the analysis to identify possible determinants of PSA concentration to improve the accuracy of PSA tests. METHODS Associations between PSA and the above-mentioned clinical parameters were examined among 14,486 men who visited our hospital for a routine health checkup, using linear regression analyses. RESULTS Total of 1403 (9.7%) and 784 (5.4%) men were classified as diabetes and obesity, respectively. After adjusting age, significant PSA reductions were found in diabetic men, especially for men taking antidiabetics. Such association was seen when the diabetic status was represented by hemoglobin A1c (HbA1c) and fasting blood sugar (FBS) levels. That is, PSA levels were significantly reduced in men with higher HbA1c and FBS levels. Obesity was also associated with a reduction in PSA levels. Moreover, PSA levels were significantly decreased with increased ALT levels. CONCLUSIONS PSA test results should be carefully interpreted especially for men with diabetes and obesity, in whom a substantial reduction in PSA concentration is likely to occur.

中文翻译：

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血清前列腺特异性抗原水平与糖尿病、肥胖、高血压以及与葡萄糖耐量、肝功能和血脂相关的实验室参数之间的关联：对修改前列腺特异性抗原阈值的影响。

背景 先前的研究表明，除了年龄和 PSA 之间已建立的正相关之外，体重指数 (BMI)、糖尿病和前列腺特异性抗原 (PSA) 浓度之间还存在负相关。还提出了临床参数之间的其他因果关系，包括高血压、肝功能、测试、血脂和 PSA。因此，我们将这些参数全部合并到分析中，以确定 PSA 浓度的可能决定因素，从而提高 PSA 测试的准确性。方法 使用线性回归分析在 14,486 名到我院进行常规健康检查的男性中检查 PSA 与上述临床参数之间的关联。结果 总共有 1403 名 (9.7%) 和 784 名 (5.4%) 男性分别被归类为糖尿病和肥胖症。调整年龄后，在糖尿病男性中发现了显着的 PSA 降低，特别是对于服用抗糖尿病药物的男性。当糖尿病状态由血红蛋白 A1c (HbA1c) 和空腹血糖 (FBS) 水平表示时，就会看到这种关联。也就是说，HbA1c 和 FBS 水平较高的男性的 PSA 水平显着降低。肥胖也与 PSA 水平降低有关。此外，随着 ALT 水平的升高，PSA 水平显着降低。结论 应仔细解释 PSA 检测结果，尤其是对于患有糖尿病和肥胖症的男性，因为他们的 PSA 浓度可能会大幅降低。HbA1c 和 FBS 水平较高的男性的 PSA 水平显着降低。肥胖也与 PSA 水平降低有关。此外，随着 ALT 水平的升高，PSA 水平显着降低。结论 应仔细解释 PSA 检测结果，尤其是对于患有糖尿病和肥胖症的男性，因为他们的 PSA 浓度可能会大幅降低。HbA1c 和 FBS 水平较高的男性的 PSA 水平显着降低。肥胖也与 PSA 水平降低有关。此外，随着 ALT 水平的升高，PSA 水平显着降低。结论 应仔细解释 PSA 检测结果，尤其是对于患有糖尿病和肥胖症的男性，因为他们的 PSA 浓度可能会大幅降低。