In research on cell biology, organelles have been a major unit of such analyses. Researchers have assumed that the inside of an organelle is almost uniform in regards to its function, even though each organelle has multiple functions. However, we are now facing conundrums that cannot be resolved so long as we regard organelles as functionally uniform units. For instance, how can cells control the diverse patterns of glycosylation of various secretory proteins in the endoplasmic reticulum and Golgi in an orderly manner with high accuracy? Here, we introduce the novel concept of organelle zones as a solution; each organelle has functionally distinct zones, and zones in different organelles closely interact each other in order to perform complex cellular functions. This Copernican Revolution from organelle biology to organelle zone biology will drastically change and advance our thoughts about cells.Key words: organelle zone, contact site, ER stress, Golgi stress, organelle autoregulation.

中文翻译：

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细胞器区。

在细胞生物学研究中，细胞器已成为此类分析的主要单元。研究人员认为，即使每个细胞器都有多种功能，细胞器的内部在功能方面也几乎是一致的。但是，只要我们将细胞器视为功能统一的单位，我们现在就面临着无法解决的难题。例如，细胞如何以有序的方式高精度地控制内质网和高尔基体中各种分泌蛋白的各种糖基化模式？在这里，我们介绍细胞器区域的新概念作为解决方案。每个细胞器具有功能上不同的区域，并且不同细胞器中的区域彼此紧密相互作用，以执行复杂的细胞功能。