Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that play key roles in embryonic development and stem cell proliferation of Metazoa. Both morphogens signal through heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor family and there are several other similarities that suggest a common evolutionary origin of the Hh and Wnt pathways. There is evidence that the secreted protein, Wnt inhibitory factor 1 (WIF1) modulates the activity of both Wnts and Hhs and may thus contribute to the intertwining of these pathways. In this article, we review the structure, evolution, molecular interactions and functions of WIF1 with major emphasis on its role in carcinogenesis.

中文翻译：

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Wnt抑制因子1（一种控制Wnt和刺猬通路的分泌蛋白）的结构，功能和疾病相关性。

Wnts和Hedgehogs（Hh）是大型的脂质修饰的细胞外形态发生剂，在后生动物的胚胎发育和干细胞增殖中起关键作用。两种形态发生素均通过G蛋白偶联受体家族的七螺旋卷曲蛋白型受体发出信号，并且还有其他一些相似之处表明Hh和Wnt途径的共同进化起源。有证据表明，分泌的蛋白质Wnt抑制因子1（WIF1）调节Wnt和Hhs的活性，因此可能有助于这些途径的相互缠绕。在本文中，我们将回顾WIF1的结构，进化，分子相互作用和功能，重点是其在致癌作用中的作用。