Biliary atresia (BA) is characterized by progressive destruction of the biliary system leading to liver fibrosis and deterioration of liver function. Serum hepatocyte growth factor (HGF) has been shown to be increased in cirrhotic diseases including BA. The aim of this study was to investigate the prognostic value of HGF levels in sera and liver tissue for the further disease course. A total of 49 serum and liver samples from infants with BA were acquired during Kasai-portoenterostomy (KPE) and analyzed by multiplex immunoassay including HGF, as marker of liver regeneration, and Interleukin 6 (IL-6) as a marker of inflammation. Both mediators showed no correlation with the outcome defined as favorable (survival with native liver (SNL)) or, in contrast, rapid deterioration of liver function requiring transplantation. Our data suggest that the degree of liver regeneration indicated by high levels of HGF within the liver is a dismissible factor in the post-KPE disease course.

中文翻译：

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开赛-肠胃造口术在肝脏和血清中的肝细胞生长因子水平不能预示胆道闭锁婴儿的临床结局。

胆道闭锁（BA）的特征是逐渐破坏胆道系统，导致肝纤维化和肝功能恶化。血清肝细胞生长因子（HGF）已显示在包括BA在内的肝硬化疾病中升高。这项研究的目的是研究血清和肝组织中HGF水平对进一步疾病进程的预后价值。在Kasai-portoenter造口术（KPE）期间共采集了49例BA患儿的血清和肝脏样品，并通过多重免疫分析进行了分析，包括HGF作为肝再生的标志物以及IL-6（IL-6）作为炎症的标志物。两种介体均与定义为良好的结果（天然肝生存（SNL））无相关性，相反，肝功能的快速恶化需要移植。