Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.

中文翻译：

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白介素11在疾病中的新兴作用。

白细胞介素（IL）-11属于30年前发现的细胞因子IL-6家族。尽管早期研究的重点是IL-11刺激巨核细胞生成的能力，但这种细胞因子对炎性疾病和癌症的重要性才刚刚开始被发现。这篇综述概述了我们对IL-11生物学的了解的最新进展，并着重介绍了新疗法的发展，该疗法可能通过这种细胞因子在多种疾病中进行临床靶向。