Heart failure caused by cardiomyocyte loss and fibrosis is a leading cause of death worldwide. Although current treatments for heart failure such as heart transplantation and left ventricular assist device implantation have obvious value, new approaches are needed. Endogenous adult cardiomyocyte renewal is measurable but inefficient and inadequate in response to extensive acute heart damage. Stimulating self‐renewal of endogenous cardiomyocytes holds great promise for heart repair. Uncovering the genetic mechanisms underlying cardiomyocyte renewal is a critical step in developing new approaches to repairing the heart. Recent studies have revealed that the inhibition of the Hippo pathway is sufficient to promote the proliferation of endogenous cardiomyocytes, indicating that the manipulation of the Hippo pathway in the heart may be a promising treatment for heart failure in the future. We summarize recent findings that have shed light on the function of the Hippo pathway in heart regeneration. We also discuss the mechanisms by which Hippo pathway inhibition promotes heart regeneration and how the Hippo pathway responds to different types of injury or stress during the regenerative process.

中文翻译：

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河马通路在心脏再生中的调节和功能。

由心肌细胞丢失和纤维化引起的心力衰竭是全世界死亡的主要原因。尽管目前用于心力衰竭的治疗方法（例如心脏移植和左心辅助设备植入术）具有明显的价值，但仍需要新的方法。内源性成人心肌细胞的更新是可测量的，但对广泛的急性心脏损伤的反应效率不高且不足。刺激内源性心肌细胞的自我更新对于心脏修复具有广阔的前景。揭示心肌细胞更新的遗传机制是开发修复心脏新方法的关键步骤。最近的研究表明，抑制Hippo途径足以促进内源性心肌细胞的增殖，表明在心脏中操纵Hippo途径可能是将来治疗心力衰竭的有前途的方法。我们总结了最近的发现，这些发现揭示了河马通路在心脏再生中的功能。我们还讨论了河马途径抑制促进心脏再生的机制，以及河马途径如何在再生过程中对不同类型的损伤或压力作出反应。