Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.

中文翻译：

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抗菌隐形眼镜的开发-从实验室到诊所。

隐形眼镜的佩戴通常是安全的，并提供出色的视力。然而，隐形眼镜的佩戴通常与发展眼表感染和炎症的风险有关，在严重的情况下，感染会导致视力丧失。抗菌肽涂层隐形眼镜已经制成，有助于减少感染和炎症的发生。本文回顾了从概念，实验室研究和临床前测试到抗菌隐形眼镜临床测试的最新信息的研究进展。我们提供了有关所遵循的途径和遇到的陷阱的见解。这一过程并不总是线性或平稳的，但是已经导致了一些首次公开发表的对人体抗菌肽涂层隐形眼镜的临床测试。