Bacteria are relevant in rodent quality assurance programmes if (a) the animals are at risk and (b) presence in the animals makes a difference for animal research or welfare, for example because the agent regulates clinical disease progression or impacts its host in other ways. Furthermore, zoonoses are relevant. Some bacterial species internationally recommended for the health monitoring of rats and mice, that is, Citrobacter rodentium, Corynebacterium kutscheri, Salmonella spp. and Streptococcus pneumonia, are no longer found in either laboratory or pet shop rats or mice, while there is still a real risk of impact on animal research and welfare from Filobacterium rodentium, Clostridium piliforme, Mycoplasma spp., Helicobacter spp. and Rodentibacter spp., while Streptobacillus moniliformis may be considered a serious zoonotic agent in spite of a very low risk. Modern molecular techniques have revealed that there may, depending on the research type, be equally good reasons for knowing the colony status of some commensal bacteria that are essential for the induction of specific rodent models, such as Alistipes spp., Akkermansia muciniphila, Bifidobacterium spp., Bacteroides fragilis, Bacteroides vulgatus, Faecalibacterium prausnitzii, Prevotella copri and segmented filamentous bacteria. In future, research groups should therefore consider the presence or absence of a short list of defined bacterial species relevant for their models. This list can be tested by cost-effective sequencing or even a simple multiple polymerase chain reaction approach, which is likely to be cost-neutral compared to more traditional screening methods.

中文翻译：

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小鼠和大鼠的质量保证中应考虑细菌种类。

细菌与啮齿动物质量保证计划有关，如果（a）动物处于危险之中，并且（b）动物存在会对动物研究或福利产生影响，例如因为该药物调节临床疾病进展或以其他方式影响其宿主。此外，人畜共患病也很重要。国际上推荐用于大鼠和小鼠健康监测的某些细菌种类，即啮齿类柠檬酸杆菌，库氏棒状杆菌，沙门氏菌。在实验室或宠物商店的老鼠或老鼠中都不再发现肺炎链球菌和肺炎链球菌，而啮齿类杆菌，梭状梭状芽孢杆菌，支原体，Helicobacter spp仍然存在影响动物研究和福利的真正风险。和Rodentibacter spp。，尽管危险性很低，但仍可将莫尼氏链球菌视为严重的人畜共患病原体。现代分子技术表明，根据研究类型的不同，可能同样有充分的理由来了解某些共生细菌的菌落状态，这些细菌对于诱导特定的啮齿动物模型至关重要，例如，阿利斯特斯菌，阿克曼曼丝菌，双歧杆菌。 ，例如，脆弱的拟杆菌，寻常型拟杆菌，普氏嗜藻杆菌，普氏杆菌和分段丝状细菌。因此，将来，研究小组应考虑是否存在与其模型相关的明确细菌种类的简短列表。可以通过经济高效的测序甚至简单的多重聚合酶链反应方法来测试此列表，