This paper is a response to a letter from Dr. H Tennekes ("The Resilience of the Beehive" Journal of Toxicology and Environmental Health B 20: 316-386). Here we emphasize that our quantitative weight of evidence analyses were focused on the level of the honeybee colony. These colony-level responses include redundancy and resiliency as well as a number of possible sublethal effects of pesticides on the colony. We also note that the literature has shown that binding of neonicotinoid insecticides to the nicotinic acetylcholine receptor is reversible. The comments in this letter do not provide reasons to change our conclusions, that, as currently used in good agricultural practices as seed-treatments, imidacloprid, clothianidin, and thiamethoxam do not present significant risks to honeybees at the level of the colony.

中文翻译：

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回应Tennekes（2018）“蜂巢的弹性”，《毒理学与环境健康杂志》 B 20：316-386。

本文是对H. Tennekes博士的来信（“蜂巢的韧性”，《毒理学与环境健康杂志》 B 20：316-386）的回应。在这里，我们强调证据分析的定量权重集中在蜜蜂菌落的水平上。这些菌落水平的反应包括冗余和适应力，以及农药对菌落的许多亚致死作用。我们还注意到，文献表明新烟碱类杀虫剂与烟碱型乙酰胆碱受体的结合是可逆的。这封信中的评论并没有提供改变我们结论的理由，因为吡虫啉，可比丁胺和噻虫嗪目前在良好的农业实践中被用作种子处理剂，因此不会对蜜蜂的蜂群造成重大风险。