Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibited apoptosis, inflammation and fibrosis, whereas Sirt-1 and survival signaling were suppressed. Pathological conditions other than survival signaling were improved in the DM + ADSC group. All pathological conditions were improved in the DM + R + ADSC group. Also, the oxidative stress level in the blood was reduced in the DM + R + ADSC group compared to the sham group. Oral resveratrol administration appears to reduce oxidative damage and enhances survival signaling in diabetic liver. The therapeutic response in the DM + R + ADSC group was better than in the DM + ADSC group.

中文翻译：

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口服白藜芦醇可增强自体移植的脂肪干细胞对糖尿病性肝病​​大鼠的治疗作用。

干细胞疗法是治疗因糖尿病（DM）引起的肝病的一种有前途的疗法。口服白藜芦醇治疗具有保护作用。我们研究了接受自体脂肪干细胞移植（ADSC）加口服白藜芦醇的糖尿病大鼠肝脏是否可能产生保护作用。将雄性大鼠分为四组：假手术组；假手术组。链脲佐菌素诱导的DM组；DM + ADSC组，其中DM大鼠用106个干细胞/大鼠治疗；DM + R + ADSC组，其中DM大鼠接受ADSC和口服白藜芦醇治疗。DM组表现出凋亡，炎症和纤维化，而Sirt-1和生存信号被抑制。DM + ADSC组除生存信号外的病理状况得到改善。DM + R + ADSC组所有病理状况均得到改善。此外，与假手术组相比，DM + R + ADSC组的血液中氧化应激水平降低。口服白藜芦醇似乎可以减少氧化损伤并增强糖尿病肝脏的生存信号。DM + R + ADSC组的治疗反应优于DM + ADSC组。