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Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials.
American Journal of Cardiovascular Drugs ( IF 2.8 ) Pub Date : 2019-08-19 , DOI: 10.1007/s40256-019-00368-y Liye Shi 1 , Ling Chen 1 , Guoxian Qi 1 , Wen Tian 1 , Shijie Zhao 1
中文翻译:
冠状动脉内尼古兰地对急性心肌梗死患者心肌微循环和临床结果的影响:一项随机对照试验的荟萃分析。
更新日期:2019-08-19
American Journal of Cardiovascular Drugs ( IF 2.8 ) Pub Date : 2019-08-19 , DOI: 10.1007/s40256-019-00368-y Liye Shi 1 , Ling Chen 1 , Guoxian Qi 1 , Wen Tian 1 , Shijie Zhao 1
Affiliation
Background
The amelioration of myocardial reperfusion in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PPCI) remains a significant issue.Objective
We conducted a meta-analysis of randomized controlled trials (RCTs) to better assess the effects of intracoronary nicorandil administration on myocardial microcirculation and clinical outcomes in these patients.Methods
The meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. A literature search was performed in the PubMed, Embase, Cochrane Library, and Web of Science databases up to April 2019, with no time or language limitations. Pooled risk ratios (RRs) were calculated to evaluate the treatment effects.Results
Seven RCTs involving a total of 562 patients were included. Compared with control, intracoronary nicorandil significantly reduced the incidence of thrombolysis in myocardial infarction (TIMI) grade ≤ 2 (RR 0.349; 95% confidence interval [CI] 0.199–0.611; P < 0.001) and TIMI myocardial perfusion grade ≤ 2 (RR 0.611; 95% CI 0.438–0.852; P = 0.004) and was associated with higher complete ST-segment resolution rates (RR 1.326; 95% CI 1.090–1.614; P = 0.005). However, no significant benefits were observed on clinical outcomes, including death (RR 0.370; 95% CI 0.085–1.618; P = 0.187), recurrent myocardial infarction (RR 0.507; 95% CI 0.156–1.655; P = 0.261), heart failure (RR 0.528; 95% CI 0.224–1.247; P = 0.145), and target lesion/vessel revascularization (RR 1.109; 95% CI 0.553–2.224; P = 0.770).Conclusions
Intracoronary nicorandil can significantly improve myocardial microcirculation in patients with AMI undergoing PPCI, but it failed to offer clinically significant benefits.中文翻译:
冠状动脉内尼古兰地对急性心肌梗死患者心肌微循环和临床结果的影响:一项随机对照试验的荟萃分析。