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RNA regulatory processes in RNA virus biology.
WIREs RNA ( IF 6.4 ) Pub Date : 2019-04-29 , DOI: 10.1002/wrna.1536
Shaun T Cross 1 , Daniel Michalski 1 , Megan R Miller 1 , Jeffrey Wilusz 1
Affiliation  

Numerous post-transcriptional RNA processes play a major role in regulating the quantity, quality and diversity of gene expression in the cell. These include RNA processing events such as capping, splicing, polyadenylation and modification, but also aspects such as RNA localization, decay, translation, and non-coding RNA-associated regulation. The interface between the transcripts of RNA viruses and the various RNA regulatory processes in the cell, therefore, has high potential to significantly impact virus gene expression, regulation, cytopathology and pathogenesis. Furthermore, understanding RNA biology from the perspective of an RNA virus can shed considerable light on the broad impact of these post-transcriptional processes in cell biology. Thus the goal of this article is to provide an overview of the richness of cellular RNA biology and how RNA viruses use, usurp and/or avoid the associated machinery to impact the outcome of infection. This article is categorized under: RNA in Disease and Development > RNA in Disease.

中文翻译:

RNA病毒生物学中的RNA调节过程。

转录后的许多RNA过程在调节细胞中基因表达的数量,质量和多样性方面起着重要作用。这些包括RNA加工事件,例如加帽,剪接,聚腺苷酸化和修饰,还包括RNA定位,衰变,翻译和非编码RNA相关调控等方面。因此,RNA病毒的转录本与细胞中各种RNA调节过程之间的界面具有显着影响病毒基因表达,调节,细胞病理学和发病机制的巨大潜力。此外,从RNA病毒的角度了解RNA生物学可以为这些转录后过程对细胞生物学的广泛影响提供可观的启示。因此,本文的目的是概述细胞RNA生物学的丰富性,以及RNA病毒如何使用,篡夺和/或避免影响感染结果的相关机制。本文归类于:疾病与发展中的RNA>疾病中的RNA。
更新日期:2019-11-01
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