Excessive magnitudes of compressive stress exerted on gastrointestinal tissues can lead to pathological scar tissue or adhesion formation, bleeding, inflammation or even death from bowel perforation and sepsis. It is currently unknown however, at exactly what magnitude of compressive stress that these pathologies occur. A novel simple compressive device was engineered to provide an objective means of producing discrete compressive stresses on human tissues. Samples of human large intestine (colon) were removed from consenting patients as a part of their standard surgical procedure. These samples were compressed with a range of loads normally produced by standard laparoscopic graspers in representative abdominal surgeries. After compression, specimens were processed for histological analysis and assessed. The two independent pathologists who were blinded to stress magnitudes were both able to quantify increasing tissue damage that corresponded to increasing amounts of compressive force. A threshold between 350–450 kPa was discovered that corresponded to both significant serosal thickness change and a positive histological trauma score rating. Whether the tissue injury quantified is pathologic is subject for future in-vivo longitudinal investigation but certainly based on literature, can be the basis of pathological adhesion formation or an area for hemorrhage and scar formation.

中文翻译：

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确定人大肠腹腔镜手术中压缩应力与组织创伤之间的关系

对胃肠组织施加过大的压缩应力会导致病理性瘢痕组织或粘连形成、出血、炎症甚至因肠穿孔和败血症而死亡。然而，目前尚不清楚这些病理发生的压缩应力的大小。设计了一种新颖的简单压缩装置，以提供一种在人体组织上产生离散压缩应力的客观手段。作为标准外科手术的一部分，从同意的患者身上取出人类大肠（结肠）的样本。在典型的腹部手术中，这些样本通常由标准腹腔镜抓取器产生的一系列负载压缩。压缩后，标本进行组织学分析和评估。两位对压力大小不了解的独立病理学家都能够量化与增加的压缩力相对应的组织损伤的增加。发现 350-450 kPa 之间的阈值对应于显着的浆膜厚度变化和积极的组织学创伤评分等级。量化的组织损伤是否是病理性的，是未来体内纵向研究的主题，但肯定基于文献，可以是病理性粘连形成或出血和瘢痕形成区域的基础。发现 350-450 kPa 之间的阈值对应于显着的浆膜厚度变化和积极的组织学创伤评分等级。量化的组织损伤是否是病理性的，是未来体内纵向研究的主题，但肯定基于文献，可以是病理性粘连形成或出血和瘢痕形成区域的基础。发现 350-450 kPa 之间的阈值对应于显着的浆膜厚度变化和积极的组织学创伤评分等级。量化的组织损伤是否是病理性的，是未来体内纵向研究的主题，但肯定基于文献，可以是病理性粘连形成或出血和瘢痕形成区域的基础。